We need your help now

Support from readers like you keeps The Journal open.

You are visiting us because we have something you value. Independent, unbiased news that tells the truth. Advertising revenue goes some way to support our mission, but this year it has not been enough.

If you've seen value in our reporting, please contribute what you can, so we can continue to produce accurate and meaningful journalism. For everyone who needs it.

A researcher holds a human brain in a laboratory at Northwestern University's cognitive neurology and Alzheimer's disease center in Chicago

Gene mutation speeds up brain decline in Alzheimer's

This is the first study to use brain scans to show what this gene does.

A RARE GENETIC mutation associated with Alzheimer’s disease has been found to accelerate the loss of brain tissue and lead to quicker mental decline, researchers said.

People with the TREM2 gene variant lost brain tissue twice as fast as healthy elderly people, according to research published in the New England Journal of Medicine.

“This is the first study to use brain scans to show what this gene variant does, and it’s very surprising,” said co-author Paul Thompson of the University of Southern California.

This gene speeds up brain loss at a terrific pace.

Thompson and colleagues did MRI scans on 478 adults, whose average age was 76, over the course of two years.

They found that mutation carriers lost 1.4 percent to 3.3 percent more of their brain tissue than non-carriers, and the deterioration happened twice as fast.

Brain tissue loss was concentrated in memory centers of the brain, including the temporal lobe and hippocampus.

The TREM2 variant was first described in January as rare mutation, existing in about one percent of the North American and European population, that could triple a person’s lifetime risk of Alzheimer’s disease.

The genetic mutation has also been linked to an increased likelihood of Parkinson’s disease and a rare form of early brain decline called Nasu-Hakola disease.

Read: Drug tests make Alzheimer’s treatment ‘a real possibility’>

Your Voice
Readers Comments
    Submit a report
    Please help us understand how this comment violates our community guidelines.
    Thank you for the feedback
    Your feedback has been sent to our team for review.