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Lower death rates for those taking cholesterol medication and exercise - study

New research also shows that the benefits of physical fitness outweigh those of cholesterol lowering medication.

Image: Tyler Olson via Shutterstock

TAKING CHOLESTEROL MEDICATION or being even modestly physically fit significantly improves survival in people with dyslipidaemia - abnormal levels of harmful blood fats or cholesterol, according to new research.

The research, published online first in The Lancet also shows that combining statin (cholesterol lowering drugs) treatment with better fitness may do more to ward off death than either intervention alone.

Most strikingly, the study found that even people with dyslipidaemia not taking statins, but who were highly fit, were roughly half as likely to die from any cause during the median 10-year follow up than those taking statins, but who were unfit.

Peter Kokkinos from the Veterans Affairs Medical Center, Washington DC, who led the research explained:

The fitness necessary to attain protection that is much the same or greater than that achieved by statin treatment in unfit individuals is moderate and feasible for many middle-aged and older adults through moderate intensity physical activity such as walking, gardening, and gym classes.

In the USA, approximately 71 million adults have elevated LDL-cholesterol according to Center for Disease Control. Dyslipidaemia is a key contributor to the incidence of coronary heart disease.

Kokkinos and colleagues assessed the records of over 10,000 veterans with dyslipidaemia from Veterans Affairs hospitals in Washington DC and Palo Alto, California, USA.

All participants were given a standard exercise tolerance test between the years 1986 and 2011 to determine their exercise capacity. Using a measure of the peak metabolic rate (MET) achieved while exercising, the researchers classified fitness level as least, moderate, fit, or high.

Patients were then divided into two groups (those treated with statins and not treated with statins) within each fitness category.

Death rates

The researchers found that death rates were lowest for those who were taking statins and were physically fit. The higher the level of fitness the lower the risk of dying during the median follow-up period of 10 years. The fittest participants, regardless of whether they were taking statins, had a significantly (60–70 per cent) lower risk of death.

The difference in death risk could not be explained by factors such as age, body mass, ethnicity, sex, history of cardiovascular disease, risk factors for cardiovascular disease, and medications.

In light of the findings Kokkinos recommends, “Individuals with dyslipidaemia should improve their fitness to at least a moderate level.”

“Treatment with statins is important, but better fitness improves survival significantly and is a valuable additional treatment or an alternative when statins cannot be taken,” he said.

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